PKMYT1-IN-11
PKMYT1-IN-11 (Example 1) is a PKMYT1 inhibitor with an IC50 of 4.49 nM. PKMYT1-IN-11 inhibits the proliferation of HCC1569 cells. When combined with Gemcitabine (HY-17026), PKMYT1-IN-11 shows a significant anti-tumor effect in the OVCAR3 xenograft mouse model. PKMYT1-IN-11 can be used for the study of various cancers such as breast cancer and ovarian cancer[1].
Product Specifications
CAS Number
[3097325-25-9]
UNSPSC
12352005
Target
Wee1
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
NC1=C(C(N)=O)C2=C([N@@]1[C@@]3=C(C)C(O)=C(F)C=C3C)N=C(C)C(C(F)(F)F)=C2
Molecular Formula
C18H16F4N4O2
Molecular Weight
396.34
References & Citations
[1]Wang, et al. Pharmaceutical combination of PKMYT1 inhibitor and use thereof. WO2025167971.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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