ER degrader 12
ER degrader 12 (Example 1) is an estrogen receptor (ER) degrader with IC50 values for ERα and ERβ of 2.3 and 80.2 nM respectively (TR-FRET experiment) . ER degrader 12 inhibits the proliferation of MCF-7 cells, with an IC50 of 1.53 nM. ER degrader 12 can be used for research on breast cancer[1].
Product Specifications
CAS Number
[2376991-14-7]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=C(C2C3=C(CC(C)N2CC(C)C)C4=C(N=NN4)C=C3)C(F)=CC(OCCN5CC(C5)CF)=C1
Molecular Formula
C26H32F3N5O
Molecular Weight
487.56
References & Citations
[1]Zhu CG, et al. Estrogen receptor degrading agent for treating breast cancer. WO2019192533.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
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