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M-1111

M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer[1].

Product Specifications

CAS Number

1887095-86-4

UNSPSC

12352005

Target

MTOR

Related Pathways

PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](OCCOCC5=CN(CCOCCOCCOCCOCCOCCOCCOCCNC(CCCCN6C7=C(C(N)=NC=N7)C(C8=CC(N=C(N)O9)=C9C=C8)=N6)=O)N=N5)CC4)OC)C)=O)=O

Molecular Formula

C89H134N12O23

Molecular Weight

1740.08

References & Citations

[1]Kevan Shokat, et al. Disclosed herein, inter alia, are compounds and methods of using the same for modulating the activity of mTORCl. WO2016040806.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MTORC1

Frequently Asked Questions

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