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ALK2-IN-6

ALK2-IN-6 (Compound 14a) is a selective ALK2 inhibitor, with an IC50 of 9 nM. ALK2-IN-6 can be used in the research of diffuse intrinsic pontine glioma[1].

Product Specifications

CAS Number

2600795-23-9

UNSPSC

12352005

Target

TGF-β Receptor

Related Pathways

TGF-beta/Smad

Field of Research

Cancer

Smiles

CN(CC1)CCN1C(C=C2)=CC=C2C3=C(C)C(C4=CC(OC)=C(C(OC)=C4)OC)=CN=C3

Molecular Formula

C26H31N3O3

Molecular Weight

433.54

References & Citations

[1]Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63 (17) :10061-10085.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ALK2

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