IAfaPhos1

IAfaPhos1 is a FKBP12F36V epimer ligand. iAfaPhos1 leads to reduced dephosphorylation of EGFR at pY1068 and pY845 sites. iAfaPhos1 has anticancer activity against non-small cell lung cancer[1].

Product Specifications

UNSPSC

12352211

Target

EGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=C(COC1=CC([C@@H](CCC2=CC=C(C(OC)=C2)OC)OC([C@H]3CCCCN3C([C@H](C4=CC(OC)=C(C(OC)=C4)OC)CC)=O)=O)=CC=C1)NCCOCCOCCN(C/C=C/C(NC5=CC6=C(C=C5OC)N=CN=C6NC7=CC=C(C(Cl)=C7)F)=O)C

Molecular Formula

C64H77ClFN7O14

Molecular Weight

1222.79

References & Citations

[1]Hu Z, et al. EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling. Sci Adv. 2024 Mar 29;10 (13) :eadj7251.