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Tau-aggregation-IN-5

Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC50 = 0.31 μM) . Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases[1].

Product Specifications

CAS Number

1283397-08-9

UNSPSC

12352005

Target

Tau Protein

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C(C1=CNC2=C1C=CC(N)=C2)NC3=CC=CC=C3

Molecular Formula

C15H13N3O

Molecular Weight

251.28

References & Citations

[1]Conway LP, et al. Discovery of a tau-aggregate clearing compound that covalently targets P4HB. Cell Chem Biol. 2025 Oct 16;32 (10) :1235-1248.e34.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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