Tau-aggregation-IN-5
Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC50 = 0.31 μM) . Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases[1].
Product Specifications
CAS Number
[1283397-08-9]
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=CNC2=C1C=CC(N)=C2)NC3=CC=CC=C3
Molecular Formula
C15H13N3O
Molecular Weight
251.28
References & Citations
[1]Conway LP, et al. Discovery of a tau-aggregate clearing compound that covalently targets P4HB. Cell Chem Biol. 2025 Oct 16;32 (10) :1235-1248.e34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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