ONO-2570366
ONO-2570366 (Compound 11a) is an antagonist of the cysteinyl leukotriene receptors CysLT1R and CysLT2R (IC50 = 14 nM) . ONO-2570366 inhibits the binding of LTD4[1].
Product Specifications
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=C(O)[C@H]1OC2=C(C=CC=C2N(C1)CCCC(O)=O)NC(C3=CC=C(C=C3)OCCCCC4=CC(F)=CC=C4Cl)=O
Molecular Formula
C30H30ClFN2O7
Molecular Weight
585.02
References & Citations
[1]Gusach A, et al. Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors. Nat Commun. 2019 Dec 6;10 (1) :5573.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-176921/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LTC4/CysLT2; LTD4/CysLT1
Curated Selection
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