PROTAC STAT6 degrader-3

PROTAC STAT6 degrader-3 (Compound I-677) is a potent STAT6 PROTAC degrader with a DC50 of less than 1 nM. PROTAC STAT6 degrader-3 can be used for research on allergic/inflammatory diseases and cancer.

Product Specifications

CAS Number

[3077385-98-6]

UNSPSC

12352005

Target

PROTACs; STAT

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(N(C)C)C(N1)=CC2=C1C(F)=C(C3=CCCN(C(CCN4N=CC=C4)=O)C3)C=C2C5=C(F)C(F)=C(N6CCN(C7=C(F)C=C(NC8CCC(NC8=O)=O)C(OC)=C7)CC6)C=C5

Molecular Formula

C44H45F4N9O5

Molecular Weight

855.88

References & Citations

[1]Bin Yang, et al. STAT6 DEGRADERS AND USES THEREOF CROSS REFERENCE TO RELATED APPLICATIONS. WO2025049820A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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