K-Ras ligand-Linker Conjugate 8
K-Ras ligand-Linker Conjugate 8 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for KRAS (HY-162960) and a PROTAC linker, which recruits E3 ligases. K-Ras ligand-Linker Conjugate 8 can be used for synthesis of PROTAC KRAS (on) degrader ACBI-4 (HY-176792) [1].
Product Specifications
UNSPSC
12352005
Target
Ras; Target Protein Ligand-Linker Conjugates
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
CC(C)[C@@H](C(O)=O)N1N=NC2=C1CC[C@@H](C2)CCCN3C[C@H](C)N(C4=NC(C5=NOC([C@]6(C)C7=C(SC(N)=C7C#N)CCC6)=N5)=CC=N4)CCC3
Molecular Formula
C36H47N11O3S
Molecular Weight
713.90
References & Citations
[1]Vetma V, et al. Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS (On) Alleles. J Am Chem Soc. 2025 Oct 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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