E3 ligase Ligand 76
E3 ligase Ligand 76 is a E3 ligase ligand that can be used in the recruitment of VHL protein. E3 ligase Ligand 76 can be connected to the KRAS ligand by a linker to synthesis of PROTAC KRAS (on) degrader ACBI-4 (HY-176792).
Product Specifications
UNSPSC
12352211
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@H]1CN[C@@H](C1)C(NCC2=CC=C3C(N(C)N=C3)=C2)=O.Cl
Molecular Formula
C14H19ClN4O2
Molecular Weight
310.78
References & Citations
[1]Vetma V, et al. Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS (On) Alleles. J Am Chem Soc. 2025 Oct 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Frequently Asked Questions
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