E3 ligase Ligand 76

E3 ligase Ligand 76 is a E3 ligase ligand that can be used in the recruitment of VHL protein. E3 ligase Ligand 76 can be connected to the KRAS ligand (HY-162960) by a linker to synthesis of PROTAC KRAS (on) degrader ACBI-4 (HY-176792) [1].

Product Specifications

UNSPSC

12352211

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[C@H]1CN[C@@H](C1)C(NCC2=CC=C3C(N(C)N=C3)=C2)=O.Cl

Molecular Formula

C14H19ClN4O2

Molecular Weight

310.78

References & Citations

[1]Vetma V, et al. Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS (On) Alleles. J Am Chem Soc. 2025 Oct 30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

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