ML-93

ML-93 is an orally active SAE inhibitor, with an IC50 value of 0.4 μM. ML-93 inhibits the SUMOylation pathway in HCT116 cells. ML-93 shows robust antitumor activity in the HCT116 colorectal carcinoma xenograft model. ML-93 can be used for the study of colorectal cancer[1].

Product Specifications

CAS Number

[1858275-91-8]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

CC1=C(C=C(S1)C(C2=CN=CN=C2N[C@@H]3C[C@@H]([C@H](C3)O)COS(N)(=O)=O)=O)[C@H]4C5=CC(Cl)=CC=C5CCO4

Molecular Formula

C25H27ClN4O6S2

Molecular Weight

579.09

References & Citations

[1]Langston SP, et al. Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J Med Chem. 2021 Mar 11;64 (5) :2501-2520.