NSC126188
NSC126188 is a RhoB inducer. NSC126188 can induce apoptosis by inhibiting Akt/FoxO3 signaling. NSC126188 can be used for the research of cancer, such as prostate cancer[1].
Product Specifications
CAS Number
[31863-82-8]
UNSPSC
12352005
Target
Akt; Apoptosis; FOXO; ROCK
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C(CCCCCCCCCCCCCCC)N1CC[N+](C)(CC1)C.[I-]
Molecular Formula
C22H45IN2O
Molecular Weight
480.51
References & Citations
[1]Won KJ, et al. NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription. Apoptosis. 2014 Jan;19 (1) :179-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
FOXO3
Curated Selection
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