JTT251
JTT251 is a PDHK inhibitor. JTT251 binds to the allosteric lipoamidebinding domain, resulting in only partial inhibition of PDHK enzymatic activity. JTT251 can be used for the research of cancer[1].
Product Specifications
CAS Number
[1627957-25-8]
Target
PDHK
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
FC(F)([C@@]1(C2=CC(OCCC(C)(O)C)=CC(C3=CN(N=C3)C(C)(C)C(N)=O)=C2C4=CC=CC=C41)O)F
Molecular Formula
C26H28F3N3O4
Molecular Weight
503.51
References & Citations
[1]Xu H, et al. Discovery of ATP competitive PDHK1/2 dual inhibitors. Bioorg Med Chem Lett. 2025 Jul 1;122:130190.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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