Glucocorticoid receptor/IL-6-IN-2

Glucocorticoid receptor/IL-6-IN-2 (Compound 36) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 40 nM and 19 nM, respectively) . Glucocorticoid receptor/IL-6-IN-2 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma[1].

Product Specifications

CAS Number

[1198784-83-6]

UNSPSC

12352005

Target

Glucocorticoid Receptor; Interleukin Related

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC(Cl)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N

Molecular Formula

C22H23ClF3N3O4S

Molecular Weight

517.95

References & Citations

[1]Harcken C, et al. Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate. ACS Med Chem Lett. 2014 Nov 20;5 (12) :1318-23.