Glucocorticoid receptor/IL-6-IN-1

Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 120 nM and 59 nM, respectively) . Glucocorticoid receptor/IL-6-IN-1 inhibits IL-6-induced JAK/STAT3 phosphorylation, blocking inflammatory cytokine transcription. Glucocorticoid receptor/IL-6-IN-1 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma[1].

Product Specifications

CAS Number

[1198784-71-2]

UNSPSC

12352005

Target

Glucocorticoid Receptor; Interleukin Related; JAK; STAT

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=CC(F)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N

Molecular Formula

C22H23F4N3O4S

Molecular Weight

501.49

References & Citations

[1]Harcken C, et al. Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate. ACS Med Chem Lett. 2014 Nov 20;5 (12) :1318-23.