Glucocorticoid receptor/IL-6-IN-1
Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 120 nM and 59 nM, respectively) . Glucocorticoid receptor/IL-6-IN-1 inhibits IL-6-induced JAK/STAT3 phosphorylation, blocking inflammatory cytokine transcription. Glucocorticoid receptor/IL-6-IN-1 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma[1].
Product Specifications
CAS Number
1198784-71-2
UNSPSC
12352005
Target
Glucocorticoid Receptor; Interleukin Related; JAK; STAT
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC(F)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N
Molecular Formula
C22H23F4N3O4S
Molecular Weight
501.49
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; STAT3
Frequently Asked Questions
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