CoREST/LSD1 degrader-1
CoREST/LSD1 degrader-1 (Compound 4) is a molecular glue degrader targeting the KBTBD4 E3 ubiquitin ligase. CoREST/LSD1 degrader-1 is promising for research of KBTBD4-mutant driven cancers (e.g., medulloblastoma) and epigenetic dysregulation disorders[1].
Product Specifications
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=C(C=C1)C3=C(N2)N=C(CC4=CC=CC=C4)N=C3N[C@@H]5CC[C@H](CC5)N(C)C)OC
Molecular Formula
C27H31N5O2
Molecular Weight
457.57
References & Citations
[1]Chen Z, et al. Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment. Nat Commun. 2025 Apr 2;16 (1) :3144.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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