PROTAC SMARCA2 degrader-35

PROTAC SMARCA2 degrader-35 (Compound 43) is a selective SMARCA2 PROTAC degrader with a DC50 [1][2]. Pink: SMARCA2 ligand (HY-178414) ; Blue: E3 ligase ligand; Black: linker

Product Specifications

CAS Number

[3032998-97-0]

UNSPSC

12352005

Target

DNA/RNA Synthesis; PROTACs; SWI/SNF Complex

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Field of Research

Cancer

Smiles

OC1=C(F)C=CC=C1C2=NN=C3C(N(C[C@H](OC4=NC=C(CN5CCN(C6=CC=C7C(C(N([C@@H]8C(NC(CC8)=O)=O)C7)=O)=C6)CC5)C=C4)C9)[C@@]9(C(F)F)CN3)=C2

Molecular Formula

C39H38F3N9O5

Molecular Weight

769.77

References & Citations

[1]Corey H B, et al. BRM Targeting Compounds And Associated Methods Of Use. US20240165244A1. 2024-05-23.|[2]Ito K, et al. Combination treatment regimens - smarca2 degrader with taxane anticancer agent. WO2025194059A1. 2025-09-18.