KRAS-IN-42
KRAS-IN-42 (Compound Z1063) is a covalent KRASG12D mutants inhibitor. KRAS-IN-42 is promising for research of KRASG12D-mutant cancers (e.g., non-small cell lung cancer, colorectal cancer) [1].
Product Specifications
CAS Number
3033641-67-4
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
FC1=C(C2=CC(N)=CC3=C2C(C#C)=C(F)C=C3)N=C4C5=C1N=C(N=C5N(C[C@]6([H])N[C@@]7([H])CC6)[C@]7([H])[C@H](C)O4)OC[C@@]89N(CCC9)CC/C8=C(F)/F
Molecular Formula
C36H33F4N7O2
Molecular Weight
671.69
References & Citations
[1]Jiang T, et al. Pyrimidine-fused ring compound, and preparation method therefor and use thereof. WO2024061370A1. 2024-03-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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