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Di (5- (methylsulfonyl) -1,3,4-oxadiazol-2-yl) -benzene-amide-PEG4-ester-2,3,5,6-F-Ph

Selected Variant

HY-176863

Size: 1 Each

Di (5- (methylsulfonyl) -1,3,4-oxadiazol-2-yl) -benzene-amide-PEG4-ester-2,3,5,6-F-Ph (Compound L-1026) is a linker that connects Androgen Receptor (AR) RNAi agent to targeting ligands (such as antibodies) . The conjugation can inhibit AR gene expression and reduce AR activity. Di (5- (methylsulfonyl) -1,3,4-oxadiazol-2-yl) -benzene-amide-PEG4-ester-2,3,5,6-F-Ph can be used for spinal and bulbar muscular atrophy (SBMA) research[1].

Product Specifications

CAS Number

3094598-90-7

UNSPSC

12352005

Target

Androgen Receptor

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Neurological Disease

Smiles

O=C(CCOCCOCCOCCOCCC(NC1=CC(C2=NN=C(S(=O)(C)=O)O2)=CC(C3=NN=C(S(=O)(C)=O)O3)=C1)=O)OC4=C(F)C(F)=CC(F)=C4F

Molecular Formula

C30H31F4N5O13S2

Molecular Weight

809.72

References & Citations

[1]Esau C, et al. Rnai agents for inhibiting expression of androgen receptor (ar), compositions thereof, and methods of use. WO2025160224A1. 2025-07-31.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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