NEK7 degrader-1
NEK7 degrader-1 (Compound 17) is a NEK7 degrader with a DC50 of 0.1 nM. NEK7 degrader-1 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NEK7 degrader-1 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].
Product Specifications
CAS Number
[3069891-91-1]
UNSPSC
12352005
Target
Caspase; Interleukin Related; NEKs; NOD-like Receptor (NLR)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C)C=N3)=O)C=C2Cl)Cl)=O
Molecular Formula
C21H22Cl2N4O3
Molecular Weight
449.33
References & Citations
[1]Liardo E, et al. Substituted piperidinediones for targeted protein degradation. WO2025024521A1. 2025-01-30.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; IL-1; NEK7; NLRP3
Available Sizes
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