[Ru (dpp) (bpy) (mtmp) ] (PF6) 2

[Ru (dpp) (bpy) (mtmp) ] (PF6) 2 (Compound 5) is a trisheteroleptic ruthenium complex. [Ru (dpp) (bpy) (mtmp) ] (PF6) 2 has a light-activated anticancer activity. [Ru (dpp) (bpy) (mtmp) ] (PF6) 2 can selectively cleave off upon green light irradiation, thereby releasing a phototoxic ruthenium-based photoproduct that binds to nuclear DNA, induces DNA damage and apoptosis in cancer cells. [Ru (dpp) (bpy) (mtmp) ] (PF6) 2 can be used for phototherapy of cancers like conjunctival melanoma research[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

C[S]1CC2=CC=CC=[N]2[Ru+2]134(OC(C(O4)=O)=O)[N]5=CC=C(C6=CC=CC=C6)C7=CC=C(C(C8=CC=CC=C8)=CC=[N]93)C9=C75.F[P-](F)(F)(F)(F)F.F[P-](F)(F)(F)(F)F

Molecular Formula

C33H25F12N3O4P2RuS

Molecular Weight

950.63

References & Citations

[1]Chen Q, et al. Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model. Chem Sci. 2022 May 16;13 (23) :6899-6919.