PROTAC STAT6 degrader-1
PROTAC STAT6 degrader-1 (Compound I-2) is a STAT6 PROTAC degrader with a DC50[1]. Pink: STAT6 ligand (HY-176864) ; Blue: CRBN ligase ligand (HY-45512) ; Black: linker
Product Specifications
CAS Number
[3077464-21-9]
UNSPSC
12352005
Target
PROTACs; STAT
Related Pathways
JAK/STAT Signaling; PROTAC; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
CN(C(N1C(CCC(N2)=O)C2=O)=O)C3=C1C=CC=C3CCCN(CC4)CCN4C5=CC=C(C6=C7C(NC(C(N(C)C)=O)=C7)=CC(C8=CCCN(C(CCN9N=NC=C9)=O)C8)=C6)C=C5
Molecular Formula
C47H53N11O5
Molecular Weight
851.99
References & Citations
[1]Yang B, et al. Stat6 degraders and uses thereof. WO2025049820A1. 2025-03-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT6
Available Sizes
Curated Selection
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