PI3K/mTOR-IN-18
PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K/mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM) . PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation (IC50=144 nM) . PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC) [1].
Product Specifications
CAS Number
[1220699-39-7]
UNSPSC
12352005
Target
MTOR; PI3K
Related Pathways
PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C1N([C@H]2CC[C@@H](CC2)O)C3=C(N1C)C=NC4=CC=C(C5=CN=C(OC)C=C5)N=C34
Molecular Formula
C22H23N5O3
Molecular Weight
405.45
References & Citations
[1]Cheng H, et al. Discovery of the Highly Potent PI3K/mTOR Dual Inhibitor PF-04979064 through Structure-Based Drug Design. ACS Med Chem Lett. 2012 Nov 7;4 (1) :91-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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