DDR1-IN-12
DDR1-IN-12 (Compound 7t) is a highly selective discoidin domain receptor 1 (DDR1) inhibitor (IC50=0.126 μM) . DDR1-IN-12 blocks receptor tyrosine kinase autophosphorylation and downstream signaling (e.g., inhibition of TGF-β1-induced fibroblast activation), inhibiting tumor cell migration and pulmonary fibrosis progression. DDR1-IN-12 is promising for research of lung cancer (especially lung adenocarcinoma) [1].
Product Specifications
CAS Number
3038810-93-1
UNSPSC
12352005
Target
Discoidin Domain Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NCC1=CN(CC(N2CCN(CC2)C)=O)C3=C1C=C(F)C=C3)NC4=CC=C(C(F)(F)F)C=C4
Molecular Formula
C24H25F4N5O2
Molecular Weight
491.48
References & Citations
[1]Liu S, et al. Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis. Eur J Med Chem. 2024 Feb 5;265:116100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DDR1
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