SKLB-Y13
SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 μM. SKLB-Y13 binds to the m6A recognition pocket and disrupts m6A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; YTHDF
Related Pathways
Apoptosis; Epigenetics
Field of Research
Cancer
Smiles
ClC1=CN=C(N=C1NC2=C(C3=C(S2)CN(CC3)CC4=CC=CC=C4Cl)C(N)=O)C5=CC=NN5C
Molecular Formula
C23H21Cl2N7OS
Molecular Weight
514.43
References & Citations
[1]Wu Y, et al. Identification of a Selective YTHDF1 Inhibitor Targeting the m6A Recognition Domain for Breast Cancer. Angew Chem Int Ed Engl. 2025 Aug 19:e202509316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
YTHDF1; YTHDF2; YTHDF3
Available Sizes
Curated Selection
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