SKLB-Y13

SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 μM. SKLB-Y13 binds to the m6A recognition pocket and disrupts m6A-dependent YTHDF1-PRPF6 mRNA interaction, impairing the translation of PRPF6 and inhibiting breast cancer proliferation while promoting apoptosis. SKLB-Y13 has antitumor activity, promising for cancers therapies targeting RNA epigenetic Readers[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; YTHDF

Related Pathways

Apoptosis; Epigenetics

Field of Research

Cancer

Smiles

ClC1=CN=C(N=C1NC2=C(C3=C(S2)CN(CC3)CC4=CC=CC=C4Cl)C(N)=O)C5=CC=NN5C

Molecular Formula

C23H21Cl2N7OS

Molecular Weight

514.43

References & Citations

[1]Wu Y, et al. Identification of a Selective YTHDF1 Inhibitor Targeting the m6A Recognition Domain for Breast Cancer. Angew Chem Int Ed Engl. 2025 Aug 19:e202509316.