HNF4A-IN-1
HNF4A-IN-1 (Compound 17) is a Hepatocyte nuclear factor 4 alpha (HNF4A) inhibitor. HNF4A-IN-1 has potent anticancer activity against human head and neck squamous cells (SCC131 cells) and with no toxicity to normal cells. HNF4A-IN-1 significantly inhibits SCC131 cells growth with an IC50 of 1.75 μM, and induces apoptosis and G2/M cell cycle arrest. HNF4A-IN-1 promotes tumor regression in SCC131 tumor xenografts mouse models[1].
Product Specifications
CAS Number
[2408759-14-6]
UNSPSC
12352005
Target
Apoptosis; Orphan Nuclear Receptor
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C1N[C@@H](C2=CC=C(C=CC=C3)C3=C2)NC4=C1C=C(OC(F)(F)F)C=C4
Molecular Formula
C19H13F3N2O2
Molecular Weight
358.31
References & Citations
[1]Tentu S, et al. DHQZ-17, a potent inhibitor of the transcription factor HNF4A, suppresses tumorigenicity of head and neck squamous cell carcinoma in vivo. J Cell Physiol. 2018 Mar;233 (3) :2613-2628.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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