PNR-3-82
PNR-3-82 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.61 μM for EndoG over DNase I. PNR-3-82 does not inhibit five cell death-related enzymes including DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-82 has a cytoprotective activity and blocks Cisplatin and Docetaxel (HY-B0011) -induced cell death. PNR-3-82 can be used for cell injuries research[1].
Product Specifications
CAS Number
1424353-64-9
UNSPSC
12352005
Target
Endonuclease
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(OC)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S
Molecular Formula
C25H17N3O4S
Molecular Weight
455.49
References & Citations
[1]Jang DS, et al. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb;34 (2) :92-100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TNF alpha (J2D10), CF405S conjugate, 0.1mg/mL
CD106 / VCAM1 (1.4C3), CF740 conjugate, 0.1mg/mL
Cytokeratin 17 (E3), CF740 conjugate, 0.1mg/mL
CD43 (T-Cell Marker) (SPN/1766R), CF568 conjugate, 0.1mg/mL
MyoD1 (5.8A + MYD712), CF405S conjugate, 0.1mg/mL
