PNR-3-80

PNR-3-80 is a selective Apoptotic endonuclease G (EndoG) inhibitor with an IC50 of 0.67 μM for EndoG over DNase I. PNR-3-80 does not have inhibitory activities for DNase II, RNase A, proteinase, lactate dehydrogenase and superoxide dismutase 1. PNR-3-80 has a potent cytoprotective activity, and it significantly protects human prostate carcinoma cells from Cisplatin (HY-17394) and Docetaxel (HY-B0011) -induced cell death and represses Etoposide (HY-13629) -induced DNA damage and autophagy. PNR-3-80 can be used for cell injuries research[1][2].

Product Specifications

CAS Number

[1424353-63-8]

UNSPSC

12352005

Target

Endonuclease

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C1NC(NC(/C1=C\C2=CN(C3=C2C=C(Cl)C=C3)C(C4=CC5=C(C=CC=C5)C=C4)=O)=O)=S

Molecular Formula

C24H14ClN3O3S

Molecular Weight

459.90

References & Citations

[1]Wang W, et al. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nat Commun. 2021 Jan 20;12 (1) :476. |[2]Jang DS, et al. Novel cytoprotective inhibitors for apoptotic endonuclease G. DNA Cell Biol. 2015 Feb;34 (2) :92-100.