3-Deoxy-3-fluoro-D-fructose
3-Deoxy-3-fluoro-D-fructose (Compound 12) is a derivative of 2,5-Anhydro-D-mannitol. 3-Deoxy-3-fluoro-D-fructose is a selective probe of Hexose transporter 5 (GLUT5) . 3-Deoxy-3-fluoro-D-fructose inhibits the transport of D-fructose labeled with 14C by GLUT5 with IC50s of 1.16 and 2.37 µM in EMT-6 and MCF-7 cells. 3-Deoxy-3-fluoro-D-fructose can be used for positron emission tomography (PET) imaging of cancers[1].
Product Specifications
CAS Number
[110925-86-5]
UNSPSC
12352211
Target
GLUT
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
OC[C@@H](O)[C@@H](O)[C@H](F)C(CO)=O
Molecular Formula
C6H11FO5
Molecular Weight
182.15
References & Citations
[1]Soueidan OM, et al. New fluorinated fructose analogs as selective probes of the hexose transporter protein GLUT5. Org Biomol Chem. 2015 Jun 21;13 (23) :6511-21.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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