GPR109 receptor agonist-3
GPR109 receptor agonist-3 is an orally active GPR109 receptor agonist, with an IC50 of 310 nM. GPR109 receptor agonist-3 retains the antioxidation and cytoprotection of Lipoic acid (HY-18733) . GPR109 receptor agonist-3 reduces total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and increases high-density lipoprotein cholesterol (HDL-C) in high-fat diet-fed rats. GPR109 receptor agonist-3 can be used for the study of atherosclerosis[1].
Product Specifications
CAS Number
[944559-31-3]
UNSPSC
12352005
Target
GPR109A
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease; Cardiovascular Disease
Smiles
O=C(C1=CC=CN=C1)NCCNC(CCCCC2SSCC2)=O
Molecular Formula
C16H23N3O2S2
Molecular Weight
353.50
References & Citations
[1]Jiang Y, et al. Discovery of a novel niacin-lipoic acid dimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. Eur J Pharmacol. 2020 Feb 5;868:172871.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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