VVD-849
VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research[1].
Product Specifications
CAS Number
3055321-14-4
UNSPSC
12352005
Target
PI3K; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1
Molecular Formula
C29H31ClFN3O6S2
Molecular Weight
636.15
References & Citations
[1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS6285557-01 0.2 mL
CHCHD6, ID (CHCHD6, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1) (AP)
Sign In for Pricing
View Details MBS6285557-02 5x 0.2 mL
CHCHD6, ID (CHCHD6, CHCM1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial, Coiled coil helix cristae morphology protein 1) (AP)
Sign In for Pricing
View Details 
LS000165-20ug 20 µg
AE binding protein 1 (AEBP1) (NM_001129) Human Over-expression Lysate
Sign In for Pricing
View Details orb2927864-01 20 µg
Recombinant Mouse Chloride intracellular channel protein 5 (Clic5)
Sign In for Pricing
View Details orb2927864-02 100 µg
Recombinant Mouse Chloride intracellular channel protein 5 (Clic5)
Sign In for Pricing
View Details CSB-EP023225HU-01 20 µg
Recombinant Human Tubulin-specific chaperone A (TBCA)
Sign In for Pricing
View Details