VVD-849

VVD-849 is a RAS ligand. VVD-849 binds covalently to cysteine 242 in the RAS binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2 over-expressing tumors. VVD-849 can be used cancers like breast cancer research[1].

Product Specifications

CAS Number

[3055321-14-4]

UNSPSC

12352005

Target

PI3K; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1

Molecular Formula

C29H31ClFN3O6S2

Molecular Weight

636.15

References & Citations

[1]Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001.