CDN prodrug-1
CDN prodrug-1 (Compound 2) is a STING ligand. CDN prodrug-1 consists of a cyclic dinucleotide (CDN) and a dialanine peptide linker. CDN prodrug-1 can be cleaved following internalization into endolysosomes by cathepsins and subsequently release the parent CDN. CDN prodrug-1 can be used for synthesis nanoparticles for drug delivery research[1].
Product Specifications
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@]4(COP(O[C@@H]5[C@H](O)[C@@H](COP6(SCC7=CC=C(NC([C@H](C)NC([C@H](C)NC(CCCCCN(C(C=C8)=O)C8=O)=O)=O)=O)C=C7)=O)O[C@H]5N9C=NC%10=C9N=C(N)NC%10=O)(O)=O)[C@@H](O6)[C@H]3OC4
Molecular Formula
C44H52N14O17P2S
Molecular Weight
1142.98
References & Citations
[1]Dane EL, et al. STING agonist delivery by tumour-penetrating PEG-lipid nanodiscs primes robust anticancer immunity. Nat Mater. 2022 Jun;21 (6) :710-720.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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