Legubicin
Legubicin (Doxorubicin-LNAA-Boc) is a novel conjugate of Doxorubicin (HY-15142A) and a Legumain-cleavable peptide linker. Legubicin is activated by Legumain to release leucine-doxorubicin while sparing normal tissues. Legubicin inhibits tumor cell growth and reduces DNA binding in non-legumain expressing cells. Legubicin completely arrests tumor growth in mice bearing CT26 tumors. Legubicin can be used for the study of colon carcinoma (CRC) [1].
Product Specifications
CAS Number
[606967-53-7]
Product Name Alternative
Doxorubicin-LNAA-Boc
UNSPSC
12352100
Target
Drug Derivative
Related Pathways
Others
Field of Research
Cancer
Purity
98.01
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=C2C(C(C3=C(OC)C=CC=C3C2=O)=O)=C(O)C([C@H]4O[C@@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C)NC([C@H](C)NC(OC(C)(C)C)=O)=O)=O)=O)=O)=C1C[C@](O)(C4)C(CO)=O
Molecular Formula
C48H64N6O18
Molecular Weight
1013.05
References & Citations
[1]Wang Y, et al. Biodistribution and preclinical safety profile of legubicin: A novel conjugate of doxorubicin and a legumain-cleavable peptide linker. J Appl Toxicol. 2024 Sep;44 (9) :1426-1445. |[2]Liu C, et al. Overexpression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 2003 Jun 1;63 (11) :2957-64.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Monoclonal TROY/TNFRSF19 Antibody (208) [mFluor Violet 610 SE]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NBP2-90451MFV610 0.1 mL
Rabbit Monoclonal TROY/TNFRSF19 Antibody (208) [mFluor Violet 610 SE]
Ask
View Details