TGP-377
TGP-377 is a potent miR-377 inhibitor that specifically and effectively enhances VEGFA expression by targeting the non-coding microRNA that regulates VEGFA expression[1].
Product Specifications
CAS Number
2665700-67-2
UNSPSC
12352100
Target
MicroRNA; VEGFR
Related Pathways
Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(CN(CCCN1N=NC(CN2CCN(CC2)C3=CC(NC4=NC=CC(NC5=CC=C6C=CC=CC6=N5)=C4)=NC(C)=N3)=C1)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CN(CCC)C(CCCOC7=CC(C8=NC9=CC=C(C=C9N8)N)=CC(C%10=NC%11=C(N%10)C=C(N)C=C%11)=C7)=O)=O)=O)=O)=O)N
Molecular Formula
C75H93N23O7
Molecular Weight
1428.69
References & Citations
[1]Haniff HS, et al. Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold-small molecule interactions. Nat Chem. 2020 Oct;12 (10) :952-961.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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