MF-DH-300
MF-DH-300 is a 15-PGDH inhibitor with an IC50 of 1.6 nM. MF-DH-300 blocks binding of 15-PGDH to PGE2 and increases stem cell proliferation and muscle force, as well as improves mitochondrial function. MF-DH-300 increases survival motor neuron (SMN) protein expression. MF-DH-300 can be used for muscle disorders like spinal muscular atrophy (SMA) research[1].
Product Specifications
CAS Number
[2673403-86-4]
UNSPSC
12352100
Target
15-PGDH
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Concentration
10mM
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=CC(N2C=CC3=C2N=CC(C(N4CCCCC4)=O)=C3)=C1
Molecular Formula
C20H18N4O
Molecular Weight
330.38
References & Citations
[1]WEBSTER M, et al. Methods for combination treatment of spinal muscular atrophy. WO2025019367A1. 2025-01-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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