LMD-902
LMD-902, a LMD-009 (HY-121885) analog, is a CCR8 agonist with an EC50 of 15 nM. LMD-902 has a superior binging capacity depending on key residues such as PheVI:16. LMD-902 can be used for inflammation diseases like bronchial asthma and central nervous system diseases like multiple sclerosis research[1].
Product Specifications
CAS Number
[521979-59-9]
UNSPSC
12352100
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=S(NCC)(C1=CC=C(C=C1C2(CCN(CC2)CC3=CC(OC4=C(OC)C=CC=C4)=CC=C3)O)OC)=O
Molecular Formula
C28H34N2O6S
Molecular Weight
526.64
References & Citations
[1]Jensen PC, et al. Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8. Mol Pharmacol. 2007 Aug;72 (2) :327-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR8
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