SHP2-IN-43
SHP2-IN-43 (Compound 5) is a SHP2 inhibitor with an IC50 of 98.7 nM. SHP2-IN-43 can be used as a PROTAC target ligand in the synthesis of SHP2-D26 (HY-145162) [1].
Product Specifications
CAS Number
[2458219-45-7]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; SHP2
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(C)=O
Molecular Formula
C18H23ClN6OS
Molecular Weight
406.93
References & Citations
[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. J Med Chem. 2020 Jul 23;63 (14) :7510-7528. doi: 10.1021/acs.jmedchem.0c00471. Epub 2020 May 21. Erratum in: J Med Chem. 2021 Jan 14;64 (1) :906-908.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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