CDK12-Cyclin K ligand-1
CDK12-Cyclin K ligand-1 is a ligand of PROTAC degrader that binds to the E3 ligase. CDK12-Cyclin K ligand-1 can be used in the synthesis of PROTAC degrader such as PP-C8 (HY-144691) [1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase; Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Field of Research
Others
Smiles
CC(N1C=NC2=C1N=C(N=C2NCC3=NC4=CC(F)=C(C=C4N3)F)N5CCOCC5)C
Molecular Formula
C20H22F2N8O
Molecular Weight
428.44
References & Citations
[1]Tian Niu, et al., Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor. European Journal of Medicinal Chemistry, 2022, 228, 114012.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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