CDK12-Cyclin K ligand-1

CDK12-Cyclin K ligand-1 is a ligand of PROTAC degrader that binds to the E3 ligase. CDK12-Cyclin K ligand-1 can be used in the synthesis of PROTAC degrader such as PP-C8 (HY-144691) [1].

Product Specifications

UNSPSC

12352005

Target

Ligands for E3 Ligase; Ligands for Target Protein for PROTAC

Related Pathways

PROTAC

Field of Research

Others

Smiles

CC(N1C=NC2=C1N=C(N=C2NCC3=NC4=CC(F)=C(C=C4N3)F)N5CCOCC5)C

Molecular Formula

C20H22F2N8O

Molecular Weight

428.44

References & Citations

[1]Tian Niu, et al., Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor. European Journal of Medicinal Chemistry, 2022, 228, 114012.