VUBI1-octanoic acid
VUBI1-octanoic acid is a conjugate of SOS1 ligand and linker, which can be used in the synthesis of (4S) -PROTAC SOS1 degrader-1 (HY-144657) [1].
Product Specifications
UNSPSC
12352005
Target
SOS1; Target Protein Ligand-Linker Conjugates
Related Pathways
MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(CCCCCCCCN1CCN(C2=C3N=C(N(C3=CC(Cl)=C2)CC4=CC(C)=C(C(C)=C4)F)N5CC6(C5)CNC6)CC1)O
Molecular Formula
C34H46ClFN6O2
Molecular Weight
625.22
References & Citations
[1]Zhou C, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022 Mar 10;65 (5) :3923-3942.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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