EGFR Ligand-Linker Conjugates 1

EGFR Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605) [1].

Product Specifications

CAS Number

[2768472-86-0]

UNSPSC

12352005

Target

EGFR; Target Protein Ligand-Linker Conjugates

Related Pathways

JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C=CC(N1CCC[C@@H](C1)N2C3=C(N=C2NC4=CC=CC=C4)C=NC(NC5=CC=C(C=C5)N6CCN(CC6)CCCCCCCC(O)=O)=N3)=O

Molecular Formula

C37H47N9O3

Molecular Weight

665.83

References & Citations

[1]Zhao HY, et al. Discovery of Potent PROTACs Targeting EGFR Mutants through the Optimization of Covalent EGFR Ligands. J Med Chem. 2022 Mar 24;65 (6) :4709-4726.