KRAS G12C Ligand-Linker Conjugates 1
KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRASG12C ligand and linker, which can be used in the synthesis of PROTAC YF135.
Product Specifications
CAS Number
3033236-98-2
UNSPSC
12352005
Target
Ras; Target Protein Ligand-Linker Conjugates
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(CCOCCCN1CCC[C@H]1COC2=NC3=C(C(N4CCN([C@H](C4)CC#N)C(/C(C#N)=C/C5CC5)=O)=N2)CCN(C3)C6=CC=CC7=C6C(Cl)=CC=C7)OC(C)(C)C
Molecular Formula
C45H55ClN8O5
Molecular Weight
823.42
References & Citations
[1]Yang F, et al. Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022 Feb 15;230:114088.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC940633-100 1x 100 µL
Von Willebrand Factor (3E2D10), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC401429-500 1x 500 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC880146-100 1x 100 µL
CD10 (CB-CALLA), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC040146-500 1x 500 µL
CD10 (CB-CALLA), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 