KRAS G12C Ligand-Linker Conjugates 1
KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRASG12C ligand and linker, which can be used in the synthesis of PROTAC YF135 (HY-144323) [1].
Product Specifications
CAS Number
[3033236-98-2]
UNSPSC
12352005
Target
Ras; Target Protein Ligand-Linker Conjugates
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
O=C(CCOCCCN1CCC[C@H]1COC2=NC3=C(C(N4CCN([C@H](C4)CC#N)C(/C(C#N)=C/C5CC5)=O)=N2)CCN(C3)C6=CC=CC7=C6C(Cl)=CC=C7)OC(C)(C)C
Molecular Formula
C45H55ClN8O5
Molecular Weight
823.42
References & Citations
[1]Yang F, et al. Efficient targeted oncogenic KRASG12C degradation via first reversible-covalent PROTAC. Eur J Med Chem. 2022 Feb 15;230:114088.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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