MCB-36
MCB-36 is a VHL-recruiting pan-KRAS PROTAC degrader without affecting KRAS transcription. MCB-36 exhibits minimal effects on HRAS and NRAS protein levels. MCB-36 binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities Kd ≈ 1 pM) . MCB-36 decreases p-ERK levels, leading to cell apoptosis. MCB-36 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-36 can be used for the study of colorectal cancer and lung cancer (Pink: Target protein ligand; Blue: E3 ligand (HY-112078) ; Black: Linker (HY-W091879) ) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; p38 MAPK; PERK; PROTACs; Ras; TNF Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
Molecular Formula
C60H71F2N9O7S
Molecular Weight
1100.32
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-176786/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; K-Ras
Available Sizes
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