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GNE-5152

GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].

Product Specifications

CAS Number

3080315-83-6

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

O=C1N(CCC(C1)C2=CC=C(C(F)=C2)F)C3=CC=C(C4=CC=NC=C4)N=C3

Molecular Formula

C21H17F2N3O

Molecular Weight

365.38

References & Citations

[1]Leahey R, et al. SARM1 orthosteric base exchange inhibitors cause subinhibitory SARM1 activation[J]. bioRxiv, 2024: 2024.08. 06.606489.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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