Guanidino ethyl disulfide
Guanidino ethyl disulfide (GED) (Compound 23) is a NO Synthase (NOS) inhibitor with EC50s of 110, 630 and 180 μM for iNOS, eNOS and bNOS, respectivly. Guanidino ethyl disulfide effectively inhibits nitrite production in J774.2 macrophages. Guanidino ethyl disulfide can be used for circulatory shock, inflammation and neurological diseases research[1].
Product Specifications
CAS Number
[1072-13-5]
UNSPSC
12352211
Target
NO Synthase
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Smiles
N=C(NCCSSCCNC(N)=N)N
Molecular Formula
C6H16N6S2
Molecular Weight
236.36
References & Citations
[1]Southan G J, et al. Spontaneous rearrangement of aminoalkylisothioureas into mercaptoalkylguanidines, a novel class of nitric oxide synthase inhibitors with selectivity towards the inducible isoform[J]. British journal of pharmacology, 1996, 117 (4) : 619-632.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ENOS; iNOS; nNOS
Curated Selection
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