GPX4-IN-17

GPX4-IN-17 (Compound 9i) is an inhibitor of GPX4 with potent cytotoxicity (IC50 = 0.3 nM) . GPX4-IN-17 shows strong binding affinity against GPX4 (KD = 20.4 nM) . GPX4-IN-17 inhibits tumor growth in the xenograft tumor mouse model without detectable cytotoxicity. GPX4-IN-17 can enhance cancer chemotherapy and overcome tumor resistance. GPX4-IN-17 can be studied in antitumor reseach[1].

Product Specifications

CAS Number

[3035800-33-7]

UNSPSC

12352005

Target

Glutathione Peroxidase

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(C1=CSC(C#C)=N1)N(C(C2=CSC3=CC=CC=C32)C(NC(C)(C)C)=O)C4=CC=C(C5=CN=CO5)C=C4

Molecular Formula

C29H24N4O3S2

Molecular Weight

540.66

References & Citations

[1]Sunkai Gu, et al., Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead. J. Med. Chem. 2025, 68, 3, 3309–3323