N-Benzyl-N-demethylpronqodine A

N-Benzyl-N-demethylpronqodine A (Compound 16) is an inhibitor of NAD (P) H:quinine acceptor oxidoreductase 1 (NQO1) with an IC50 of 83.3 nM[1].

Product Specifications

CAS Number

[1810092-90-0]

UNSPSC

12352005

Target

NADPH Oxidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C(NCC1=CC=CC=C1)=C2)C3=C(SN=C3)C2=O

Molecular Formula

C14H10N2O2S

Molecular Weight

270.31

References & Citations

[1]Blunt CE, et al., Synthesis and Intracellular Redox Cycling of Natural Quinones and Their Analogues and Identification of Indoleamine-2,3-dioxygenase (IDO) as Potential Target for Anticancer Activity. Angew Chem Int Ed Engl. 2015 Jul 20;54 (30) :8740-5. doi: 10.1002/anie.201503323. Epub 2015 Jun 10. PMID: 26096359.