CCL-34
CCL-34 is a Toll-like receptor 4 (TLR4) activator. CCL-34 significantly induced dendritic cell (DC) CD83 expression and IL-12p70 production in a dose-dependent manner, thereby inducing DC maturation. CCL-34 enhanced the allostimulatory activity of DC on naive CD4+CD45+RA+ T cell proliferation and IFN-γ secretion. CCL-34 further induced antigen presentation ability in mice inoculated with doxorubicin-treated colorectal cancer cells. CCL-34 can be used in studies of immune stimulation.
Product Specifications
CAS Number
[943316-60-7]
UNSPSC
12352211
Target
Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
CCCCCCCCCCCNC([C@@H](NC(CCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@@H]([C@@H]([C@H]1O)O)O)CO)=O
Molecular Formula
C32H62N2O8
Molecular Weight
602.84
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR4
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